Relevant Publications

Young, M.F. and J.R. Fallon. (2012) Biglycan: a promising new therapeutic for neuromuscular and musculoskeletal diseases. Curr. Opin. Genet. Dev. 22(4):398-400.

Amenta, A.R., H.E. Creely , M.L. Mercado, H. Hagiwara, B.A. McKechnie, S. Rossi, Q. Wang, R.T. Owens, L. Mei, W. Hoch, M.F. Young, D.J. McQuillan, R.L. Rotundo, and J.R. Fallon. (2012) Biglycan is a MuSK ligand that regulates agrin signaling and is important for neuromuscular junction stability. J. Neurosci. 32(7):2324 –2334.

Amenta, A.R., A. Yilmaz, S. Bogdanovich, B.A. McKechnie, M. Abedi, T.S. Khurana, and J.R. Fallon. (2011). Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice. Proc. Natl. Acad. Sci. USA. 108: 762-767.

Brandan, E., C. Cabello-Verrugio, and C. Vial. (2008) Novel regulatory mechanisms for the proteoglycans decorin and biglycan during muscle formation and muscular dystrophy. Matrix Biol. 27:700-8.

Rafii, M.S., H. Hagiwara, M.L. Mercado, N.S. Seo, T. Xu, T. Dugan, M. Hook, D.J. McQuillan, M.F. Young and J.R. Fallon.  (2006) Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. J. Cell. Physiol. 209: 439-47.

Mercado, M.L.,  A. R. Amenta, H. Hagiwara, M. S. Rafii, R. T. Owens, D. J. McQuillan and  J.R. Fallon. (2006) Biglycan targets dystrobrevin, syntrophin and nNOS to the muscle cell membrane. FASEB J. 20: 1724-1726.

Lechner, B.E., J.H. Lim, M.L. Mercado, and J.R. Fallon. (2006) Developmental regulation of biglycan expression in muscle and tendon. Muscle Nerve. 34:347-55.

Scott, P.G., C.M. Dodd, E.M. Bergmann, J.K. Sheehan, and P.N. Bishop. (2006) Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans. J Biol Chem. 281:13324-32.

Casar, J.C., B.A. McKechnie, J.R. Fallon, M.F. Young, and E. Brandan. (2004) Transient up-regulation of biglycan during skeletal muscle regeneration: delayed fiber growth along with decorin increase in biglycan-deficient mice. Dev Biol. 268: 358-71.

Wiberg, C., E. Hedbom, A. Khairullina, S.R. Lamande, A. Oldberg, R. Timpl, M. Morgelin, and D. Heinegard. (2001) Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix. J Biol Chem. 276:18947-52.

Bowe, M.A., D.B. Mendis, and J.R. Fallon. (2000) The small leucine-rich repeat proteoglycan biglycan binds to alpha-dystroglycan and is upregulated in dystrophic muscle. J Cell Biol. 148:801-10.